Last Update: Sep 20th 2013

Hestar-450

Indications

  1. As a plasma volume expander in case of hypovolemia due to:
    1. haemorrhage
    2. acute trauma
    3. burns
    4. sepsis
    5. water & electrolytes loss in acute gastrointenstinal distrubances
    6. surgery
  2. Cardiac priming
  3. Therapeutic haemodilutions
  4. Leucapheresis

Contraindications

  1. Severe haemorrhagic defects
  2. Severe congestive cardiac failure
  3. Renal failure with oliguria and anuria
  4. Patients allergic to strach
  5. Hyperhydration states

Composition

Each 100 ml contains:

Hydroxyethyl Strach (450/0.7) 6.0 g
Sodium Chloride BP 0.9 g
Water for Injections BP q.s.
Average Molecular Weight 4,50,000
Degree of Substitution ~ 0.7
Osmolarity (mOsmol/L) 308
Electrolytes (mmol/L) Na+ 154, Cl- 154

Rate of Infusion

  1. In haemorrhagic shock: up to 20 ml/kg body weight/hour, 0.33 ml/kg body weight/minute.
  2. In septic and burn shock: Lower rates of infusion.

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